iced.normalization.estimate_block_biases¶

iced.normalization.estimate_block_biases(counts, lengths, cnv, verbose=False)¶

Estimates block biases

Parameters

counts : ndarray or sparse arrays (n, n)

lengths : ndarray (L, )

number of bins associated to each chromosomes.

cnv : ndarray (n, )

copy number associated to each bin. Only breakpoints are useful

Returns

block_biases : ndarray or sparse array (n, n)

The estimated block biases